2021年
  原著論文 4 Kitagawa K, Tatsumi M, Kato M, Komai S, Doi H, Hashii Y, Katayama T, Fujisawa M, and Shirakawa T. An oral cancer vaccine using a Bifidobactrerium vector suppresses tumor growth in a syngeneic mouse bladder cancer model. Molecular Therapy – Oncolytics (in press)
    3 Nakagawa A, Nakamura S, Matsumura E, Yashima Y, Takao M, Aburatani S, Yaoi K, Katayama T, and Minami H. Selection of the optimal tyrosine hydroxylation enzyme for (S)-reticuline production in Escherichia coli. Applied Microbiology and Biotechnology 105(13):5433-5447.
    2 Yoshida K, Hirano R, Sakai Y, Choi MH, Sakanaka M, Kurihara S, Iino H, Xiao JZ, Katayama T, and Odamaki T. Bifidobacterium response to lactulose ingestion in the gut relies on a solute-binding protein-dependent ABC transporter. Communications Biology 4(1):541.
    1 Akazawa H, Tsujikawa Y, Fukuda I, Suzuki Y, Choi M.-H, Katayama T, Mukai T, and Osawa R. Isolation and identification of milk oligosaccharide-degrading bacteria from the intestinal contents of suckling rats. Bioscience of Microbiota, Food and Health 40(1):27-32.
  総説 2 Ojima MN, Yoshida K, Sakanaka M, Jiang L, Odamaki T, and Katayama T (corresponding author). Ecological and molecular perspectives on responders and non-responders to probiotics and prebiotics. Current Opinion in Biotechnology 73:108-120.
    1 Katoh T and Yamamoto K. Innovative Preparation of Biopharmaceuticals Using Transglycosylation Activity of Microbial Endoglycosidases. Journal of Applied Glycoscience 68(1):1-9.
  著作 1 Urashima T, Katayama T, Fukuda K, and Hirabayashi J. Human milk oligosaccharides and innate immunity. pp 389-439 in Comprehensive Glycoscience 2nd Edition (Edited by Joseph J. Barchi Jr.).
  2020年
  原著論文 6 Katayama-Ikegami A, Byun Z, Okada S, Miyashita M, Katayama T, Sakamoto T, Ichihi A, Shimizu K, and Kanzaki S. Characterization of the recombinant UDP:flavonoid 3-O-galactosyltransferase from Mangifera indica ‘Irwin’ (MiUFGalT3) involved in skin coloring. Horticulture Journal in press.
    5 Pichler MJ, Yamada C, Shuoker B, Alvarez-Silva C, Gotoh A, Leth ML, Schoof E, Katoh T, Sakanaka M, Katayama T, Jin C, Karlsson NG, Arumugam M, Fushinobu S, and Hachem MA. Butyrate Producing Colonic Clostridiales Metabolise Human Milk Oligosaccharides and Cross Feed on Mucin via Conserved Pathways. Nature Communications 11(1):3285. DOI: 10.1038/s41467-020-17075-x.
    4 Ojima MN, Gotoh A, Takada H, Odamaki T, Xiao J-Z, Katoh T and Katayama T. Bifidobacterium bifidum Suppresses Gut Inflammation Caused by Repeated Antibiotic Disturbance Without Recovering Gut Microbiome Diversity in Mice. Frontiers in Microbiology 11:1349. DOI: 10.3389/fmicb.2020.01349.
    3 Takada H, Katoh T (corresponding author), and Katayama T. Sialylated O-Glycans from Hen Egg White Ovomucin are Decomposed by Mucin-degrading Gut Microbes. Journal of Applied Glycoscience 67(2):31-39.
    2 Umekawa M, Shiraishi D, Fuwa M, Sawaguchi K, Mashima Y, Katayama T, and Karita S. (2020). Mitotic cyclin Clb4 is required for the intracellular adaptation to glucose starvation in Saccharomyces cerevisiae. FEBS Letters 594(8):1329-1338
    1 Ashida H, Fujimoto T, Kurihara S, Nakamura M, Komeno M, Huang Y, Katayama T, Kinoshita T, and Takegawa K. 1,6-α-L-Fucosidases from Bifidobacterium longum subsp. infantis ATCC 15697 involved in the degradation of core-fucosylated N-glycan. Journal of Applied Glycoscience 67:23-29. DOI: 10.5458/jag.jag.JAG-2019_0016.
  総説 3 浦島 匡, 片山 高嶺, 福田 健二. ミルクオリゴ糖・マイクロビオータのグライコミクス. 生化学 92(3):307-322.
    2 Katoh T, Ojima MN, Sakanaka M, Ashida H, Gotoh A and Katayama T (corresponding author). Enzymatic Adaptation of Bifidobacterium bifidum to Host Glycans, Viewed from Glycoside Hydrolyases and Carbohydrate-Binding Modules. Microorganisms 8(4), 481.
    1 Sakanaka M, Gotoh A, Yoshida K, Odamaki T, Koguchi H, Xiao JZ, Kitaoka M, and Katayama T (corresponding author). Varied pathways of infant gut-associated Bifidobacterium to assimilate human milk oligosaccharides: prevalence of the gene set and its correlation with bifidobacteria-rich microbiota formation. Nutrients 12(1):7. DOI: 10.3390/nu12010071
  2019年
  原著論文 3 Sakanaka M, Hansen ME (equal contribution), Gotoh A, Katoh T, Yoshida K, Odamaki T, Yachi H, Sugiyama Y, Kurihara S, Hirose J, Urashima T, Xiao JZ, Kitaoka M, Fukiya S, Yokota A, Lo Leggio L, Abou Hachem M (corresponding author), and Katayama T (corresponding author). Evolutionary adaptation in fucosyllactose uptake systems supports bifidobacteria-infant symbiosis. Science Advances 5:eaaw7696.
    2 Toda K, Hisata K, Satoh T, Katsumata N, Odamaki T, Mitsuyama E, Katayama T, Kuhara T, Aisaka K, Shimizu T, and Xiao JZ. Neonatal oral fluid as a transmission route for bifidobacteria to the infant gut immediately after birth. Scientific Reports 9:8692.
    1 Shirakawa T, Kitagawa K, Tatsumi M, Gonoi R, Katayama T, Hashii Y, Fujisawa M, and Kadowaki M. Preclinical development of a WT1 oral cancer vaccine using a bacterial vector to treat castration-resistant prostate cancer. Molecular Cancer Therapeutics 18:980-990.
  総説 1 加藤 紀彦, 後藤 愛那, 尾島 望美, 片山 高嶺.(2019). 乳児腸管におけるビフィズスフローラ形成には母乳オリゴ糖分解物のクロスフィーディングが関与する? ミルクサイエンス 68(2):117-123.
  2018年
  原著論文 4 Gotoh A, Katoh T, Sakanaka M, Ling Y, Yamada C, Asakuma S, Urashima T, Tomabechi Y, Katayama-Ikegami A, Kurihara S, Yamamoto K, Harata G, He F, Hirose J, Kitaoka M, Okuda S and Katayama T. Sharing of human milk oligosaccharides degradants within bifidobacterial communities in faecal cultures supplemented with Bifidobacterium bifidum. Scientific Reports 8, Article number: 13958
    3 Ashida H, Tanigawa K, Kiyohara M, Katoh T, Katayama T, Yamamoto K. Bifunctional properties and characterization of a novel sialidase with esterase activity from Bifidobacterium bifidum. Bioscience, Biotechnology, and Biochemistry 82(11):2030-2039.
    2 Matsumura E, Nakagawa A, Tomabechi Y, Ikushiro S, Sakaki T, Katayama T, Yamamoto K, Kumagai H, Sato F, Minami H. Microbial production of novel sulphated alkaloids for drug discovery. Scientific Reports 8(1):7980.
    1 Higashiyama T, Umekawa M, Nagao M, Katoh T, Ashida H, Yamamoto K. Chemo-enzymatic synthesis of the glucagon containing N-linked oligosaccharide and its characterization. Carbohydrate Research 455:92-96.
  総説 2 Gotoh A, Ojima MN, and Katayama T. Minority species influences microbiota formation: The role of Bifidobacterium with extracellular glycosidases in bifidus flora formation in breast-fed infant guts. Microbial Biotechnology 12:259-264. DOI:10.1111/1751-7915.13366

    1 後藤 愛那加藤 紀彦、阪中 幹祥、片山 高嶺. ヒト母乳オリゴ糖を介した乳児腸管におけるビフィズスフローラ形成機構. 腸内フローラシンポジウム 26 腸内フローラの形成と疾患ー食・栄養・薬がどのようにかかわるのか?-(神谷茂編). p31-41. 医薬出版

  2017年
  原著論文 12 Viborg AH, Katayama T, Arakawa T, Abou Hachem M, Lo Leggio Kitaoka M, Svensson B, and Fushinobu S. Discovery of α-L-arabinopyranosidases from human gut microbiome expands the diversity within glycoside hydrolase family 42. Journal of Biological Chemistry 292(51):21092-21101.
    11 Sugiyama Y, Nara M, Sakanaka M, Gotoh A, Kitakata A, Okuda S, Kurihara S. Comprehensive analysis of polyamine transport and biosynthesis in the dominant human gut bacteria: Potential presence of novel polyamine metabolism and transport genes. Int. J. Biochem. Cell Biol. 93:52-61.
    10 Umekawa M, Ujihara M, Nakai D, Takematsu H, Wakayama M. Ecm33 is a novel factor involved in efficient glucose uptake for nutrition-responsive TORC1 signaling in yeast. FEBS Letters 591(22):3721-3729.
    9 Katayama-Ikegami A, Suehiro Y, Katayama T, Jindo K, Itamura H, and Esumi T. Recombinant expression, purification, and characterization of polyphenol oxidase 2 (VvPPO2) from ‘Shine Muscat’ (Vitis labruscana Bailey × Vitis vinifera L.). Bioscience, Biotechnology, and Biochemistry 81(12):2330-2338.
    8 Katoh T (corresponding author), Maeshibu T, Kikkawa K, Gotoh A, Tomabechi Y, Nakamura M, Liao WH, Yamaguchi M, Ashida H, Yamamoto K, and Katayama T. Identification and characterization of a sulfoglycosidase from Bifidobacterium bifidum implicated in mucin glycan utilization. Bioscience, Biotechnology, and Biochemistry 81(10):2018-2027.
    7 Gotoh A, Nara M, Sugiyama Y, Sakanaka M, Yachi H, Kitakata A, Nakagawa A, Minami H, Okuda S, Katoh T, Katayama T, and Kurihara S. Use of Gifu Anaerobic Medium for Culturing 32 Dominant Species of Human Gut Microbes and Its Evaluation Based on Short-chain Fatty Acids Fermentation Profiles. Bioscience, Biotechnology, and Biochemistry 81(10):2009-2017. (BBB論文賞)
    6 Matsuzaki C, Takagaki C, Tomabechi Y, Forsberg LS, Heiss C, Azadi P, Matsumoto K, Katoh T, Hosomi K, Kunisawa J, Yamamoto K, Hisa K. Structural characterization of the immunostimulatory exopolysaccharide produced by Leuconostoc mesenteroides strain NTM048. Carbohydrate Research 448:95-102.
    5 Tomabechi Y, Katoh T, Kunishima M, Inazu T, Yamamoto K. Chemo-enzymatic synthesis of a glycosylated peptide containing a complex N-glycan based on unprotected oligosaccharides by using DMT-MM and Endo-M. Glycoconjugate Journal 34(4):481-487.
    4 Kitagawa K, Oda T, Saito H, Araki A, Gonoi R, Shigemura K, Fujsawa M, Hashii H, Katayama T, and Shirakawa T. Development of oral cancer vaccine using recombinant Bifidobacterium displaying Wilms' tumor 1 protein. Cancer Immunology, Immunotherapy 66(6):787-798.
    3 Yamada C, Gotoh A (Co-first author), Sakanaka M, Hattie M, Stubbs KA, Katayama-Ikegami A, Hirose J, Kurihara S, Arakawa T, Kitaoka M, Okuda S, Katayama T (Co-corresponding author) and Fushinobu S. Molecular Insight into Evolution of Symbiosis between Breast-Fed Infants and a Member of the Human Gut Microbiome Bifidobacterium longum. Cell Chemical Biology 24(4):515-524. →プレスリリース

    2 Kitagawa K, Omoto C, Oda T, Araki A, Saito H, Shigemura K, Katayama T, Hotta H, Shirakawa T. Oral combination vaccine, comprising Bifidobacterium displaying hepatitis C virus nonstructural protein 3 and interferon-α, induces strong cellular immunity specific to nonstructural protein 3 in mice. Viral Immunology 30(3):196-203.
    1 Sugiyama Y, Katoh T (corresponding author), Honda Y, Gotoh A, Ashida H, Kurihara S, Yamamoto K, and Katayama T. Application study of 1,2-α-L-fucosynthase: Introduction of Fucα1-2Gal disaccharide structures on N-glycan, ganglioside, and xyloglucan oligosaccharide. Bioscience, Biotechnology, and Biochemistry 81(2):283-291
  総説 2 後藤 愛那片山 高嶺(京大院・生命)、山田 千早、伏信 進矢(東大院・農生)、櫻間晴子(京都学園大・バイオ). ラクト-N-ビオシダーゼ(LnbX)の機能から考える母乳オリゴ糖を介したビフィズス菌と母乳栄養児の共生・共進化. 酵素工学ニュース 第78号.

    1 Mimura Y, Katoh T, Saldova R, O’Flaherty R, Izumi T, Mimura-Kimura Y, Utsunomiya T, Mizukami Y, Yamamoto K, Matsumoto T, Rudd PM. (2017) Glycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and efficacy. Protein & Cell 9(1):47-62.
  2016年
  原著論文 15 Yamada C, Sawano K, Iwase N, Matsuoka M, Arakawa T, Nishida S, and Fushinobu S. Isolation and characterization of a thermostable lipase from Bacillus thermoamylovorans NB501. The Journal of General and Applied Microbiology 62(6):313-319
    14 Sugiyama Y, Nakamura A, Matsumoto M, Kanbe A, Sakanaka M, Higashi K, Igarashi K, Katayama T, Suzuki H, and Kurihara S. A novel putrescine exporter SapBCDF of Escherichia coli. Journal of Biological Chemistry 291(51):26343-26351
    13 Sakaguchi K, Katoh T, Yamamoto K. Transglycosidase-like activity of Mucor hiemalis endoglycosidase mutants enabling the synthesis of glycoconjugates using a natural glycan donor. Biotechnology and Applied Biochemistry 63(6):812-819

    12 Katoh T (corresponding author), Katayama T, Tomabechi Y, Nishikawa Y, Kumada J, Matsuzaki Y, Yamamoto K. Generation of a Mutant Mucor hiemalis Endoglycosidase that Acts on Core-fucosylated N-Glycans. Journal of Biological Chemistry 291(44):23305-23317
    11 Matsumura E, Nakagawa A, Tomabechi Y, Koyanagi T, Kumagai H, Yamamoto K, Katayama T, Sato F, and Minami H. Laboratory-scale production of (S)-reticuline, an important intermediate of benzylisoquinoline alkaloids, using a bacterial-based method. Bioscience, Biotechnology, and Biochemistry 14:1-7
    10 Sugiyama Y, Gotoh A, Katoh T, Honda Y, Yoshida E, Kurihara S, Ashida H, Kumagai H, Yamamoto K, Kitaoka M, and Katayama T (corresponding author). Introduction of H-antigens into oligosaccharides and sugar chains of glycoproteins using highly efficient 1,2-α-L-fucosynthase. Glycobiology 26(11):1235-1247

  9 Katayama-Ikegami A, Katayama T, Takai M, and Sakamoto T. Reference gene validation for gene expression studies using quantitative RT-PCR during berry development of ‘Aki Queen’ grapes. VITIS: Journal of Grapevine Research 55:157-160

    8 Katayama-Ikegami A, Sakamoto T, Shibuya K, Katayama T, and Gao-Takai M. Effects of abscisic acid treatment on berry coloration and expression of flavonoid biosynthesis genes in grape. American Journal of Plant Sciences 7:1325-1336

    7 Sakanaka M, Sugiyama Y, Kitakata A, Katayama T, and Kurihara S. Carboxyspermidine decarboxylase of the prominent intestinal microbiota species Bacteroides thetaiotaomicron is required for spermidine biosynthesis and contributes to normal growth. Amino Acids 48:2443-2451

    6 Barla F, Koyanagi T, Tokuda N, Matsui H, Katayama T, Kumagai H, Michihata T, Sasaki T, Tsuji A, and Enomoto T. The γ-aminobutyric acid-producing ability under low pH conditions of lactic acid bacteria isolated from traditional fermented foods of Ishikawa Prefecture, Japan, with a strong ability to produce ACE-inhibitory peptides. Biotechnology Reports 10:105-110.

    5 Ishida R, Sakaguchi K, Matsuzaki C, Katoh T, Ishida N, Yamamoto K, and Hisa K. Levansucrase from Leuconostoc mesenteroides NTM048 Produces a Levan Exopolysaccharide with Immunomodulating Activity. Biotechnology Letters 38(4):681-7.

    4 Matsuzaki C, Matsumoto K, Katoh T, Yamamoto K, Hisa K. Comparison of the activity to stimulate mucosal IgA production between Leuconostoc mesenteroides strain NTM048 and type strain JCM6124 in mice. Biosci. Microbiota Food Health 35(1):51-5

    3 Nakagawa A, Matsumura E, Koyanagi T, Katayama T, Kawano N, Yoshimatsu K, Yamamoto K, Kumagai H, Sato F, Minami H. Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli. Nature Communications 7:10390

    2 Hidaka M*, Gotoh A* (*equal contribution), Shimizu T, Minamisawa K, Imamura H, Uchida T. Visualization of NO3/NO2 Dynamics in Living cells by Fluorescence Resonance Energy Transfer (FRET) Imaging Employing a Rhizobial Two-Component Regulatory System. Journal of Biological Chemistry 291(5):2260-2269 (Paper of the week)

    1 Koyanagi T, Nakagawa A, Kiyohara M, Matsui H, Tsuji A, Barla F, Take H, Katsuyama Y, Tokuda K, Nakamura S, Minami H, Enomoto T, Katayama T, and Kumagai H. Tracing microbiota changes in yamahai-moto, the traditional Japanese sake starter. Bioscience, Biotechnology, and Biochemistry 80(2):399-406

  総説 苫米地 祐輔, 加藤 紀彦, 山本 憲二. 均一な糖鎖を持つバイオ医薬品の開発. Medical Science Digest 42(10):449-451.

  2 加藤 紀彦. シグレックとムチン糖鎖の相互作用を介した炎症抑制機構~ムチン糖鎖のアレルギー性免疫応答における役割. 化学と生物 54(6):375-376.

    1 Katayama T. Host-derived glycans serve as selected nutrients for the gu t microbe: Human milk oligosaccharides and bifidobacteria. Bioscience, Biotechnology, and Biochemistry 80:621-632.

  2015年
  原著論文 6 Hattie M, Ito T, Debowski AW, Arakawa T, Katayama T, Yamamoto K, Fushinobu S, and KA Stubbs. Gaining insight into the catalysis by GH20 lacto-N-biosidase using small molecule inhibitors and structural analysis. Chemical Communications 51(81):15008-11.

    5 Matsuzaki C, Hayakawa A, Matsumoto K, Katoh T, Yamamoto K, Hisa K. Exopolysaccharides Produced by Leuconostoc mesenteroides Strain NTM048 as an Immunostimulant to Enhance the Mucosal Barrier and Influence the Systemic Immune Response. Journal of Agricultural and Food Chemistry 63(31):7009-15.

    4 Gotoh A, Katoh T, Sugiyama Y, Kurihara S, Honda Y, Sakurama H, Kambe T, Ashida H, Kitaoka M, Yamamoto K, Katayama T (corresponding author). Novel substrate specificities of two lacto-N-biosidases towards β-linked galacto-N-biose-containing oligosaccharides of globo H, Gb5, and GA1. Carbohydrate Research 408:18-24.

    3 Dwyer C A, Katoh T, Michael Tiemeyer, and Russell T. Matthews. Neurons and glia modify RPTPζ/phosphacan with cell-specific O-mannosyl glycans in the developing brain. Journal of Biological Chemistry 290(16):10256-73.
    2 Kiwamoto T*,Katoh T* (*equal contribution), Evans M C, Janssen J W, Brummet E M, Hudson A S, Zhu Z, Tiemeyer M, Bochner S B. Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis. Journal of Allergy and Clinical Immunology 135(5): 1329-1340. e9.

    1 Shimada Y, Watanabe Y, Wakinaka T, Funeno Y, Kubota M, Chaiwangsri T, Kurihara S, Yamamoto K, Katayama T, Ashida H. α-N-Acetylglucosaminidase from Bifidobacterium bifidum specifically hydrolyzes α-linked N-acetylglucosamine at nonreducing terminus of O-glycan on gastric mucin. Applied Microbiology and Biotechnology 99(9):3941-8.
  総説 1 加藤紀彦、際本拓未. Siglec-Fとムチンの相互作用による好酸球炎症制御、THE LUNG perspectives 23(2):68-73.

  著書 1 Katoh T and Yamamoto K. Chapter 47, Glycoenzymes in Glycan Analysis and Synthesis. Glycoscience: Biology and Medicine (eds. by Taniguchi N, Endo T. Hart GW, Seeberger PH, Wong C.-H.). pp.379-389. Springer.


  ~2014年
  →2014年までの研究業績
   
 
 

 
 
 

 京都大学大学院 生命科学研究科 統合生命科学専攻 応用生物機構学講座 分子応答機構学分野 片山グループ 

 Katayama group. Laboratory of Molecular Biology and Bioresponse, Graduate School of Biostudies, Kyoto University